A Different Approach To Metastatic Breast Cancer Treatment另一种不同的办法，转移性乳腺癌治疗

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There is important information that more than 155,000 women in the United States currently living with metastatic breast cancer and potentially receiving treatment should know.有重要的资料，超过十五万五千妇女在美国目前居住转移性乳腺癌和潜在接受治疗应该知道的。

Metastatic breast cancer is the most advanced stage of breast cancer.转移性乳腺癌是晚期乳腺癌。 Women who are diagnosed with this disease have seen their cancer spread from the breast into other parts of their body.谁妇女被诊断患有这种疾病，看到了自己的癌细胞扩散的乳腺癌到其他部分的尸体。 There are various treatment options available today for women with this disease, including chemotherapy, which continues to play a central role in the treatment of metastatic breast cancer.有不同的治疗方案可用于妇女与这一疾病，包括化疗，继续发挥中心作用，在治疗转移性乳腺癌。

However, certain chemotherapy treatments-most notably taxanes, which are one of the most commonly used types of chemotherapy for breast cancer-must be combined with chemical solvents to be delivered into the patient's body.然而，某些化疗，最明显的紫杉烷类，这是一种最常用的类型化疗的乳腺癌患者，必须结合化学溶剂将运到病人的身体。 As a result, it can take a long time (in some cases up to three hours) for a patient to receive her chemotherapy.因此，它可以在很长一段时间（在某些情况下，最多3个小时）的患者接受了化疗。 Additionally, chemical solvents can cause serious side effects such as allergic reactions, low blood pressure, rash and shortness of breath, among others.此外，化学溶剂可能会导致严重的副作用，如过敏反应，血压低，皮疹和呼吸急促，等等。 In turn, this could prevent patients from completing their treatment.反过来，这可以防止病人完成治疗。

Offering a Different Approach提供了不同的做法

Science has yielded a different approach to treating metastatic breast cancer with a taxane chemotherapy that is free of solvents.科学已经产生了不同的方法来治疗转移性乳腺癌的紫杉烷化疗是免费的溶剂。 Abraxane® for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin bound), the only solvent-free taxane chemotherapy, uses a unique technology to enable the delivery of the anti-cancer drug paclitaxel. Abraxane ®注射用悬浮液（紫杉醇蛋白结合粒子的注射暂停） （白蛋白方向） ，唯一的无溶剂紫杉类化疗，采用独特技术，使运送抗癌药物紫杉醇。 This unique technology is based on a human protein called albumin, which is a natural carrier of nutrients throughout the body.这种独特的技术是基于人类蛋白质称为白蛋白，这是一个自然的养分承运人整个身体。

"Women diagnosed with metastatic breast cancer may not know that they have options regarding which chemotherapy they receive," commented Virginia Kaklamani, MD, DSc, assistant professor Division of Hematology/ Oncology, Northwestern University. “妇女罹患转移性乳腺癌可能不知道，他们这方面的选择，他们接受化疗， ” Kaklamani评论弗吉尼亚，马里兰州，数码相机，助理教授司血液学/肿瘤学，西北大学。 "It is important that women with this disease speak with their doctor about their treatment options, which may include solvent-free taxane chemotherapy." “重要的是，妇女与这种疾病与他们说话的医生对他们的治疗方案，其中可能包括无溶剂紫杉烷化疗。 ”

The US Food & Drug Administration approved Abraxane in January 2005 for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within six months of adjuvant chemotherapy.美国食品与药物管理局批准Abraxane在2005年1月用于治疗乳腺癌术后失败的联合化疗治疗转移性疾病或复发后六个月内，辅助化疗。 Prior therapy should have included an anthracycline unless clinically contraindicated.以前治疗应包括蒽环类，除非是临床上的禁忌。

"Abraxane is the only solvent-free taxane chemotherapy approved by the FDA for the treatment of metastatic breast cancer. Abraxane provides an important option for patients with this disease," added Dr. Kaklamani. “ Abraxane是唯一的无溶剂紫杉类化疗批准了美国用于治疗转移性乳腺癌。 Abraxane提供了一个重要的选择，患者这种疾病， ” Kaklamani博士补充说。

The most serious adverse events associated with Abraxane in the randomized metastatic breast cancer study for which FDA approval was based included neutropenia, anemia, infections, sensory neuropathy, nausea, vomiting, and myalgia/arthralgia.最严重的不良反应事件的相关Abraxane在随机转移性乳腺癌的研究而FDA批准是基于包括中性粒细胞减少症，贫血，感染，感觉神经病，恶心，呕吐，肌肉和/关节痛。 Other common adverse reactions included anemia, asthenia, diarrhea, ocular/visual disturbances, fluid retention, alopecia, hepatic dysfunction, mucositis, and renal dysfunction.其他常见的不良反应包括贫血，虚弱，腹泻，眼/视觉干扰，液体潴留，脱发，肝功能异常，黏膜和肾功能不全。

Science has yielded a different approach to treating metastatic breast cancer, with a taxane chemotherapy that is free of chemical solvents.科学已经产生了不同的方法来治疗转移性乳腺癌，以紫杉烷化疗是无化学溶剂。

Important Safety Information & Boxed Warning重要的安全信息和预警盒装

You should receive Abraxane for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) under the care of a doctor who is trained to use cancer drugs.您应该会收到Abraxane注射用悬浮液（紫杉醇蛋白结合粒子的注射暂停）的关怀下医生谁是训练有素的使用治疗癌症的药物。 Because you may have side effects from your treatment, you should get this medicine in a clinic or hospital with doctors, nurses and pharmacists who are trained to give cancer drugs.因为你可能有副作用，从您的治疗，你应该得到这种药在诊所或医院的医生，护士和药剂师谁受过严格训练，使治疗癌症的药物。

Abraxane therapy should not be given to patients with metastatic breast cancer who have low white blood cell counts, which may make you more likely to get an infection. Abraxane治疗不应当考虑到患者的转移性乳腺癌谁低，白血球计数，这可能使你更容易得到感染。 Your doctor will schedule frequent blood tests for you in order to check for low blood counts.你的医生将安排频繁抽血化验为您以检查为低血球计数。

Note: Abraxane is paclitaxel made with the human blood protein albumin.注： Abraxane是紫杉醇与人类血液蛋白白蛋白。 This makes it behave differently in the body than regular paclitaxel.这使得表现不同的机构，而不是经常紫杉醇。 DO NOT SUBSTITUTE FOR OR WITH OTHER PACLITAXEL DRUGS.不取代或与其他药物紫杉醇。

Important Safety Information重要的安全信息

One of the more important side effects associated with chemotherapy is neutropenia, which is a decrease in the number of infection-fighting white blood cells (neutrophils).一个更重要的副作用与化疗中性粒细胞减少症，这是一个人数减少感染的战斗白细胞（中性粒细胞） 。 Normal levels range from approximately 1,500 cells/mm3 to 1,800 cells/mm3 (but vary according to several factors, such as age and race).正常水平范围大约从1500 cells/mm3到1800 cells/mm3 （但是因多种因素，如年龄和种族） 。 If levels fall below 500 cells/mm3, your risk of developing an infection increases and treatment may be interrupted.如果水平低于500 cells/mm3 ，您的风险，发展中国家感染的增加和治疗可能被打断。 To avoid the risk of serious infection and fever, your doctor will monitor your absolute neutrophil count (ANC) during therapy.为了避免风险，严重的感染和发烧，您的医生将监控您的绝对中性粒细胞计数（非国大）在治疗。

Women should avoid becoming pregnant while being treated with Abraxane.妇女应避免怀孕，而正在接受治疗的Abraxane 。 Tell your doctor if you are pregnant, if you become pregnant, or you plan to become pregnant while taking Abraxane.医生告诉你如您怀孕，如果怀孕，或者你计划怀孕的同时Abraxane 。 Discuss with your doctor how Abraxane may affect fertility.与你的医生会如何Abraxane影响生育能力。 Nursing a baby while taking Abraxane is not recommended because the drug may be present in breast milk.婴儿护理的同时Abraxane不建议，因为药物可能存在于母乳。

In the randomized metastatic breast cancer study, the most important adverse events included lower white and red blood cell counts, infections, tingling and numbness, nausea, vomiting, diarrhea, muscle and joint aches, and mouth sores.在随机转移性乳腺癌的研究中，最重要的不良事件包括白人和降低红细胞计数，感染，刺痛和麻木，恶心，呕吐，腹泻，肌肉和关节疼痛，口腔溃疡和。 Other adverse reactions included weakness, visual disturbances, fluid retention, hair loss, and liver and kidney dysfunction.其他不良反应包括：虚弱，视力障碍，液体潴留，脱发，以及肝脏和肾脏功能障碍。 Low platelet counts, allergic reactions (which in rare cases were severe), cardiovascular reactions, and injection site reactions were uncommon.低血小板计数，过敏反应（在极少数情况下是严重的） ，心血管反应和注射部位的反应是罕见的。

Sensory neuropathy (numbness, tingling, or burning in the hands and feet) can occur with Abraxane and other paclitaxel medications.感觉神经病变（麻木，刺痛，或焚烧的手和脚）可能发生Abraxane和其他紫杉醇药物。 Severe sensory neuropathy can improve with proper management, as prescribed by your doctor.重度感觉神经病变可以改善与适当的管理，按您的医生。 You should tell your nurse or doctor if you experience numbness, tingling, or burning in your hands or feet while taking Abraxane.你应该告诉你的护士或医生，如果您遇到麻木，刺痛，或燃烧在您的手或脚同时Abraxane 。

Please talk to your doctor or nurse if you have questions regarding the potential side effects of Abraxane therapy.请您谈谈您的医生或护士如果你有问题的潜在副作用Abraxane治疗。

Abraxane is marketed under a copromotion agreement between Abraxis BioScience, Inc. and AstraZeneca. Abraxane是根据销售copromotion协议Abraxis生物科学公司和阿斯利康。

Abraxis Oncology is a division of Abraxis BioScience, Inc. All Abraxis BioScience, Inc. corporate names, names of services, and names of products referred to herein are trade names, service marks, and/or trademarks that are owned by or licensed to Abraxis BioScience, its divisions or its affiliates, unless otherwise noted. Abraxis肿瘤是一个分工Abraxis生物科学公司所有Abraxis生物科学公司的企业名称，姓名，服务和产品名称本文所涉及的商品名称，服务标记，和/或商标所拥有或授权Abraxis生物科学，其子公司或其附属机构，除非另有说明。

Please visit www.ABRAXANE.com for full Product Information, including Warnings, Precautions, and Contraindications.请www.ABRAXANE.com全面的产品信息，包括预警，防范和禁忌。 For the full prescribing information including BOX WARNING for Abraxane, please visit www.ABRAXANE.com.为充分处方信息，包括盒警告的Abraxane ，请访问www.ABRAXANE.com 。 For more information about ongoing clinical trials with Abraxane, visit www.clinicaltrials.gov.如需正在进行的临床试验与Abraxane ，请访问www.clinicaltrials.gov 。 Copyright 2007 Abraxis BioScience, Inc. and AstraZeneca Pharmaceuticals LP.版权所有2007 Abraxis生物科学公司和阿斯利康制药公司。 All Rights Reserved.保留所有权利。 AO-586/254622 8/07 AO-586/254622 07分之8

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